THE SPECIFIC DRIVERS OF ATOPIC DERMATITIS AREN’T ALWAYS IN PLAIN SIGHT1,2

EXPLORE A KEY SUSPECT BEHIND THE INFLAMMATION2,3

Several Th2 cytokines, including IL-13, are key drivers of inflammation in atopic dermatitis2,3

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Mechanism of Disease

The chronic, persistent nature of atopic dermatitis means it’s always there, even when patients may appear asymptomatic1
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Role of IL13 & Th2 Cytokines

IL-13 plays a central role in driving AD pathophysiology2-5
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References:

  1. Suárez-Fariñas M, Tintle S, Shemer A, et al. J Allergy Clin Immunol. 2011;127(4):954-964.e1-4.
  2. Tazawa T, Sugiura H, Sugiura Y, et al. Arch Dermatol Res. 2004;295(11):459-464.
  3. Gittler JK, Shemer A, Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2012;130(6):1344-1354.
  4. Suárez-Fariñas M, Dhingra N, Gittler J, et al. J Allergy Clin Immunol. 2013;132(2):361-370.
  5. Koppes SA, Brans R, Ljubojevic Hadzavdic S, et al. Int Arch Allergy Immunol. 2016;170(3):187-193.