Role of IL13 & Th2 Cytokines

IL-13 plays a central role in driving AD pathophysiology1-4


  • Effects of IL-13 signaling include decreased expression of important skin barrier proteins leading to a disrupted skin barrier5,6 
  • IL-13, along with additional cytokines, activates itch signaling and scratching, which further disrupts the skin barrier7,8




References:

  1. Gittler JK, Shemer A, Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2012;130(6):1344-1354.
  2. Tazawa T, Sugiura H, Sugiura Y, et al. Arch Dermatol Res. 2004;295(11):459-464.
  3. Suárez-Fariñas M, Dhingra N, Gittler J, et al. J Allergy Clin Immunol. 2013;132(2):361-370.
  4. Koppes SA, Brans R, Ljubojevic Hadzavdic S, et al. Int Arch Allergy Immunol. 2016;170(3):187-193.
  5. Nomura I, Goleva E, Howell MD, et al. J Immunol. 2003;171(6):3262-3269.
  6. Howell MD, Kim BE, Gao P, et al. J Allergy Clin Immunol. 2007;120(1):150-155.
  7. Mollanazar NK, Smith PK, Yosipovitch G. Clin Rev Allergy Immunol. 2016;51(3):263-292
  8. Oetjen LK, Mack MR, Feng J, et al. Cell. 2017;171(1):217-228.e13.