The chronic, persistent nature of atopic dermatitis means it’s always there, even when patients may appear asymptomatic1
- AD is a chronic, heterogeneous, inflammatory skin disease2
- AD is a result of immune dysregulation and skin barrier dysfunction3,4
- Several Th2 cytokines, such as IL-13, play a central role in the underlying inflammatory process5-8
- Th22 and Th1 cytokines also play an active role3,5
Illustration of initiation of acute atopic dermatitis (AD) and progression to chronic skin lesions5
Reprinted from Gittler JK, Shemer A, Suárez-Fariñas M, et al. J Allergy Clin Immunol. 2012;130(6):1344-1354. Copyright 2012, with permission from American Academy of Allergy, Asthma & Immunology.